WebJun 3, 2024 · Background FBXO11, a member of the F-box protein family, regulates the cell-cycle by promoting the degradation of Bcl-6 and p53. This protein has been implicated in … WebAug 4, 2016 · With regard to cancer, FBXO11 has been reported to be recurrently mutated or deleted in a subset of diffuse large B-cell lymphomas (DLBCLs), suggesting a putative tumor suppressor role. 3 FBXO11 has also been identified as the E3 ubiquitin ligase that targets the BCL6 oncoprotein for ubiquitin-mediated proteasomal degradation. 3. BCL6 is …
Constitutional 2p16.3 deletion including MSH6 and FBXO11 in
The gene encoding FBXO11 was found to be deleted or mutated in multiple diffuse large B cell lymphoma (DLBCL) cell lines, and this inactivation of FBXO11 contributes to increased levels BCL6 and subsequently DLBCL pathogenesis. [9] FBXO11 mutations were also identified in other human cancers, such as colon, lung, … See more F-box only protein 11 is a protein that in humans is encoded by the FBXO11 gene. See more This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box … See more • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with … See more Inactivation of FBXO11-mediated BCL6 degradation has been shown to contribute to abnormal germinal-center formation and tumorigenesis. The Caenorhabditis elegans DRE … See more WebHuman DLBCLs with FBXO11 mutations display increased levels of BCL6, and FBXO11 tumour-derived mutants have impaired abilities to induce BCL6 degradation. a, Immunohistochemical stains for BCL6 ... flex hose tv
De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals …
WebMay 23, 2024 · Intellectual disability (ID) has an estimated prevalence of 1.5–2%. In most affected individuals, its genetic basis remains unclear. Whole exome sequencing (WES) … WebNov 5, 2024 · FBXO11 depletion in human cord-blood derived CD34+ cells (CD34+ CB), combined with AML1-ETO and a KRAS mutant, promoted stem cell maintenance and myeloid malignancy in a human xenotransplant model. Mass spectrometry analysis of FLAG-FBXO11 co-immunoprecipitating proteins in K562 cells identified mitochondrial … flexhrm.klaraconsulting.se