WebJun 29, 2016 · HLHS is described as being a complex trait which means that the genetic cause is complicated. There are many factors that may be involved and, in order to fully understand the genetics, we have to take into account each one of them. Three terms commonly used to describe the genetics of HLHS are: genetically heterogeneous, … WebFamilial ALS (FALS) is clinically and genetically heterogeneous. Three genes and linkage to four additional gene loci have been identified so far and may either predominantly lead to ALS (ALSI-ALS6) or cause multisystem neurodegeneration with ALS as an occasional symptom (tauopathies, ALS-dementia complex).
Genetic heterogeneity - Wikipedia
WebChildhood Nephrotic Syndrome (NS) is clinically and genetically heterogeneous entity characterized by either relapsing, and/or chronic course with significant morbidity and mortality resulting from complications of the disease itself, and/or its therapy. Globally, NS is a very significant medical problem responsible for up to 20% of kidney failures in children. browns advertising
Genetic epidemiology of amyotrophic lateral sclerosis - PubMed
WebAbstract. Genetically heterogeneous (GH) mice and rats continue to be widely used in research even though the case for using isogenic strains has been argued repeatedly. The paper by Miller et al. in this issue appears to be the only one in the last 22 to attempt a scientific justification for the continued use of (a limited subset of) GH stocks. WebJan 1, 2009 · Congenital neutropenia comprises a variety of genetically heterogeneous phenotypic traits. Molecular elucidation of the underlying genetic defects has yielded important insights into the physiology of neutrophil differentiation and function. Non-syndromic variants of congenital neutropenia are caused by mutations in ELA2, HAX1, … WebThe skeletal dysplasias or osteochondrodysplasias are a clinically and genetically heterogeneous group of disorders of bone and/or cartilage. They are characterized by abnormalities in pattering, linear growth, differentiation, and maintenance of the human skeleton. While they have been considered to be generalized disorders of endochondral … brown safety planning