Lymphostatin
WebNational Center for Biotechnology Information WebHelicobacter pylori (Hp) causes chronic gastri-tis, peptic ulcer disease, and is an early risk factor for gastric cancer (1). To establish a chronic infection, Hp possibly evades host
Lymphostatin
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Web1 apr. 2009 · Bacterial Lymphostatin Disrupts Epithelial Barrier Function. Enteric Gram-negative bacteria can breach the intestinal epithelial barrier and cause systemic infection. Lymphostatin, a toxin produced by Gram-negative bacteria including enteropathogenic Escheria coli and Citrobacter rodentium, has been associated with bacterial virulence. Web11 mar. 2016 · Attaching and effacing Escherichia coli cause diarrhea and typically produce lymphostatin (LifA), an inhibitor of mitogen-activated proliferation of lymphocytes and pro-inflammatory cytokine synthesis. A near-identical factor (Efa1) has been reported to mediate adherence of E. coli to epithelial cells. An amino-terminal region of LifA shares homology …
Web1 aug. 2010 · Lymphostatin activity could not be reliably demonstrated in lysates of EHEC O26 : H–; however, deletion of the glycosyltransferase and cysteine protease motifs in Efa-1/LifA from enteropathogenic E. coli O127 : H6 abolished lymphostatin activity. Our data uncouple the role of Efa-1/LifA in calf colonization from effects on type III secretion ... WebTY - JOUR. T1 - Mode of action of lymphostatin, a multitalented inhibitor of lymphocyte function from attaching & effacing Escherichia coli. AU - Cassady-Cain, R. L.
Web15 sept. 2024 · The third cluster, PA O-122, contains a gene (lifA/efa-1) that codes for lymphostatin, a molecule that inhibits lymphocyte proliferation and proinflammatory cytokine production . The association of EPEC with diarrhea and poor outcomes is stronger for typical EPEC than for atypical EPEC [ 1 , 2 ], with enhanced virulence modulated for … Web26 ian. 2024 · We previously demonstrated that lymphostatin is a putative glycosyltransferase that is important in intestinal colonization of cattle by EHEC …
Web11 mar. 2016 · Attaching and effacing Escherichia coli cause diarrhea and typically produce lymphostatin (LifA), an inhibitor of mitogen-activated proliferation of lymphocytes and …
Web13 aug. 2024 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J tropical grassland journalWebActivity of Lymphostatin, A Lymphocyte Inhibitory Virulence Factor of Pathogenic Escherichia coli, is Dependent on a Cysteine Protease Motif. Bease AG, Blackburn EA, Chintoan-Uta C, Webb S, Cassady-Cain RL, Stevens MP. J … tropical grassland is calledWebResults: Lymphostatin is an effector protein encoded by lifA/efa-1 (lymphocyte inhibitory factor A/ EHEC factor for adherence). lifA/efa-1 and homologous genes have been identified in EPEC, EHEC, and mouse pathogen Citrobacter rodentium, as well as various Chlamydia strains. Multiple groups have shown that in various EHEC strains lifA/efa-1 is ... tropical grassland informationWeb1 mai 2006 · Lymphostatin is required for the ability of the murine AE pathogen Citrobacter rodentium to colonize the intestines of mice and induce crypt cell hyperplasia (Klapproth … tropical grassland is also known asWeb11 mar. 2016 · Attaching and effacing Escherichia coli cause diarrhea and typically produce lymphostatin (LifA), an inhibitor of mitogen-activated proliferation of lymphocytes and … tropical grassland invasive speciestropical grassland latitudeWebLymphostatin is a virulence factor of enteropathogenic E. coli (EPEC) and non-O157 serogroup enterohaemorrhagic E. coli. Previous studies using whole-cell lysates of EPEC showed that lymphostatin ... tropical grassland latitude range