WebbKlotho (KL) is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, … WebbAnti-Klotho antibody [EPR6856] (ab181373) Research with confidence – consistent and reproducible results with every batch Long-term and scalable supply – powered by recombinant technology for fast production Success from the first experiment – confirmed specificity through extensive validation Ethical standards compliant – production is …
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WebbThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human … WebbMayo Clinic researchers say senolytic drugs can boost a key protein in the body that may protect older people against aspects of aging and a range of diseases.… 领英上的Max Robinson: Orally-active, clinically-translatable senolytics restore α-Klotho in mice… boulanger hotte bosch
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Webb10 aug. 2024 · Klotho is a longevity-associated protein; more of it slows aging, less of it accelerates aging, at least in animal studies. While researchers have spent considerable … The klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging, [18] [19] and klotho protein has been shown to be a circulating factor detectable in serum that declines with age. Visa mer Klotho is an enzyme that in humans is encoded by the KL gene. The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. α-klotho activates FGF23, and β-klotho activates FGF19 and FGF21. … Visa mer The α-klotho gene is located on chromosome 13, and is translated into a single-pass integral membrane protein. The intracellular portion of the α-klotho protein is short (11 Visa mer Reduced α-klotho or FGF23 can result in impaired phosphate excretion from the kidney, leading to hyperphosphatemia. In mice, this leads to a phenotype characteristic of premature aging, which can be mitigated by feeding the mice a low phosphate diet. Visa mer • Biology portal • "KL klotho [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-03-20. • GenAge entry for klotho • Kim, Ji-Hee; Hwang, Kyu-Hee; Park, Kyu-Sang; Kong, In Deok; Cha, Seung-Kuy (March 2015). Visa mer Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to Visa mer α-klotho can suppress oxidative stress and inflammation, thereby reducing endothelial dysfunction and atherosclerosis. Blood plasma α-klotho is … Visa mer • Shimoyama Y, Taki K, Mitsuda Y, Tsuruta Y, Hamajima N, Niwa T (2009). "KLOTHO gene polymorphisms G-395A and C1818T are associated with … Visa mer WebbFör 1 dag sedan · Suppression of klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int. 2012; 81:640–650. doi: 10.1038/ki.2011.445 Crossref Medline Google Scholar; 122. de Oliveira RM. Klotho RNAi induces premature senescence of human cells via a … boulanger hotte recyclage