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Protein klotho

WebbKlotho (KL) is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, … WebbAnti-Klotho antibody [EPR6856] (ab181373) Research with confidence – consistent and reproducible results with every batch Long-term and scalable supply – powered by recombinant technology for fast production Success from the first experiment – confirmed specificity through extensive validation Ethical standards compliant – production is …

Howard Leonhardt on LinkedIn: Klotho, the Super-antioxidant …

WebbThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human … WebbMayo Clinic researchers say senolytic drugs can boost a key protein in the body that may protect older people against aspects of aging and a range of diseases.… 领英上的Max Robinson: Orally-active, clinically-translatable senolytics restore α-Klotho in mice… boulanger hotte bosch https://felixpitre.com

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Webb10 aug. 2024 · Klotho is a longevity-associated protein; more of it slows aging, less of it accelerates aging, at least in animal studies. While researchers have spent considerable … The klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging, [18] [19] and klotho protein has been shown to be a circulating factor detectable in serum that declines with age. Visa mer Klotho is an enzyme that in humans is encoded by the KL gene. The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. α-klotho activates FGF23, and β-klotho activates FGF19 and FGF21. … Visa mer The α-klotho gene is located on chromosome 13, and is translated into a single-pass integral membrane protein. The intracellular portion of the α-klotho protein is short (11 Visa mer Reduced α-klotho or FGF23 can result in impaired phosphate excretion from the kidney, leading to hyperphosphatemia. In mice, this leads to a phenotype characteristic of premature aging, which can be mitigated by feeding the mice a low phosphate diet. Visa mer • Biology portal • "KL klotho [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-03-20. • GenAge entry for klotho • Kim, Ji-Hee; Hwang, Kyu-Hee; Park, Kyu-Sang; Kong, In Deok; Cha, Seung-Kuy (March 2015). Visa mer Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to Visa mer α-klotho can suppress oxidative stress and inflammation, thereby reducing endothelial dysfunction and atherosclerosis. Blood plasma α-klotho is … Visa mer • Shimoyama Y, Taki K, Mitsuda Y, Tsuruta Y, Hamajima N, Niwa T (2009). "KLOTHO gene polymorphisms G-395A and C1818T are associated with … Visa mer WebbFör 1 dag sedan · Suppression of klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int. 2012; 81:640–650. doi: 10.1038/ki.2011.445 Crossref Medline Google Scholar; 122. de Oliveira RM. Klotho RNAi induces premature senescence of human cells via a … boulanger hotte recyclage

Howard Leonhardt on LinkedIn: Klotho, the Super-antioxidant …

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Protein klotho

Max Robinson no LinkedIn: Orally-active, clinically-translatable ...

WebbBackground:Klotho is an age suppressor protein whose brain function is unknown. Results:Klothoprotectshippocampalneuronsfromglutamateandamyloid -inducedoxidativedamagethroughtheinduction of the thioredoxin/peroxiredoxin system. Conclusion:Klotho is neuroprotective via the regulation of the redox system. Webbcytes or genetic variations of FGFR4 or b-klotho lead to excess bile acid concentration in the colon, resulting in activation of the G protein-coupled bile acid receptor 1 (GPBAR1, or TGR5) with enteroendocrine cell stimulation (e.g., release of 5-hydroxytryptamine) and stimulation of colonic

Protein klotho

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Webb21 mars 2024 · KL (Klotho) is a Protein Coding gene. Diseases associated with KL include Tumoral Calcinosis, Hyperphosphatemic, Familial, 3 and Tumoral Calcinosis, … WebbNew Publication by Junfeng Ma, et al. Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene when overexpressed and accelerates aging when deleted in mice. Previously, we showed that α-Klotho regulates retinal pigment epithelium (RPE) functions and protects against oxidative stress. However, the mechanisms by …

Webb2 feb. 2024 · Klotho is an anti-aging protein that is mostly secrete by the kidneys, the brain, and the thyroid. R. It plays a major role in regulating kidney function and vascular health. R. The name for the klotho gene … Webbof secreted α-Klotho protein and its body fluids concentration, we hope the kit will contribute further research of secreted α-Klotho. This kit specifically measures human secreted isoforms (secreted α-Klotho) in human serum, EDTA-plasma and cerebrospinal fluid and does not react with soluble α-Klotho derived from transmembrane α-Klotho.

Webbβ-Klotho. β-Klotho is a single-pass transmembrane protein containing 1043 amino acid residues whose expression is induced in target cells upon their differentiation. β-Klotho interacts closely with FGFR1c or FGFr4 receptor proteins to … WebbHome » Products » Protein » Recombinant / Natural Protein » Recombinant Human Klotho. ... Recombinant Human Klotho Catalogue No. P3369 Size 50μg, 200μg, 1mg Species Human Host HEK293 cells Expression region 34-549 Mol. weight 72 kDa Tags C-terminal His Tag Purity Greater than 90% as determined by SDS-PAGE

Webb20 feb. 2024 · Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid …

WebbItem PathHunter® U2OS FGFR4-β-Klotho Bioassay Kit; Company DiscoverX; Price Pricing Info Supplier Page View Company Product Page; Catalog Number 93-1060Y3-00089; Quantity 200 dp (2 x 96-well) Applications Target-Based Bioassays; Reactivity Human; Detection Target FGFR4-β-Klotho; NCBI Full Gene Name fibroblast growth factor … boulanger hp 7306Webb1 apr. 2015 · Abstract. The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-suppressor gene, has generated tremendous interest and has advanced understanding of the aging process.In mice, the overexpression of the KL gene extends the life span, whereas mutations to the KL gene shorten the life span. The … boulanger hp 305Webbbeta-Klotho, a newly described membrane protein, regulates bile acid synthesis. Fibroblast growth factor-15 (FGF-15) and FGF receptor-4 (FGFR4) knockout mice share a similar phenotype with beta-Klotho-deficient mice. FGF-15 secretion by the intestine regulates hepatic bile acid biosynthesis. boulanger hp 963WebbKlotho Antibody1, hFc Tag with the EC50 of 24.1ng/ml determined by ELISA (QC Test). Immobilized Human Beta Klotho at 2μg/ml (100μl/Well). Dose response curve for Anti-Beta Klotho Antibody2, hFc Tag with the EC50 of 34.6ng/ml determined by ELISA (QC Test). ELISA Data Human Beta Klotho Protein Cat. No. KLB-HM101 For Research Use Only boulanger hp envy 17-ch0039nfWebb3 maj 2024 · Renal mRNA and protein expression of Klotho plays important an role in progression of hypertensive renal damage in spontaneously hypertensive rats. Fosinopril up-regulates klotho mRNA in time-dependent manner, and inhibits the down-regulated expression of klotho gene induced by Ang II. boulanger hp envy x360WebbKlotho, an antiaging protein closely related to arteriosclerosis, is mainly expressed in the kidney, 3 and its expression decreases with age. 4 Klotho proteins are divided into membrane-bound, soluble and secreted forms, and circulating Klotho includes soluble and secreted forms. 5 Studies have shown that the expression of circulating blood Klotho is … boulanger hub usbWebb8 sep. 2024 · We found that up-regulated the expression of Klotho protein could effectively reduce the production of ROS, mitigate the decline in Δψm, and alleviate the decrease in the Bcl-2/Bax ratio. This suggests that Klotho may have an antioxidant and anti-apoptosis effect on sevoflurane-induced neurotoxicity. boulanger hp pavilion all-in-one 24